Chiral Columns

Protein-based Chiral HPLC Columns

CHIRALPAK®AGP

Product nameProduct typeInternal
Diameter (mm)
Length (mm)Particle size (µm)P/N
CHIRALPAK®AGPAnalytical column450530712
Analytical column4100530713
Analytical column4150530714
Analytical column350530782
Analytical column3100530783
Analytical column3150530784
Analytical column250530792
Analytical column2100530793
Analytical column2150530794
Semi-prep10100530733
Semi-prep10150530734
Guard cartridge ( x 2 )210530791
Guard cartridge ( x 2 )310530781
Guard cartridge ( x 2 )410530711
 Guard cartridge holder ( for AGP/CBH/HSA)  00081

CHIRALPAK®CBH

Product nameProduct typeInternal
Diameter (mm)
Length (mm)Particle size (µm)P/N
CHIRALPAK®CBHAnalytical column450533712
Analytical column4100533713
Analytical column4150533714
Analytical column350533782
Analytical column3100533783
Analytical column3150533784
Analytical column250533792
Analytical column2100533793
Analytical column2150533794
Semi-prep10100533733
Semi-prep10150533734
Guard cartridge ( x 2 )210533791
Guard cartridge ( x 2 )310533781
Guard cartridge ( x 2 )410533711
 Guard cartridge holder ( for AGP/CBH/HSA)  00081

CHIRALPAK®HSA

Product nameProduct typeInternal
Diameter (mm)
Length (mm)Particle size (µm)P/N
CHIRALPAK®HSAAnalytical column450534712
Analytical column4100534713
Analytical column4150534714
Analytical column350534782
Analytical column3100534783
Analytical column3150534784
Analytical column250534792
Analytical column2100534793
Analytical column2150534794
Semi-prep10100534733
Semi-prep10150534734
Guard cartridge ( x 2 )210534791
Guard cartridge ( x 2 )310534781
Guard cartridge ( x 2 )410534711
 Guard cartridge holder ( for AGP/CBH/HSA)  00081

Feature

CHIRALPAK®AGP has extremely broad applicability for the separation of chiral drugs.

Basic compounds : CHIRALPAK®AGP、CHIRALPAK®CBH

Acids, Non-protolytic compounds : CHIRALPAK®AGP、CHIRALPAK®HSA

  • CHIRALPAK®AGP has extremely broad applicability for the separation of chiral drugs.
  • The protein-based columns function entirely in the reversed-phase chromatographic mode, using buffers with low organic modifier content and at moderate pH values.
  • Possibility to dynamically improve enantioseparation.

CHIRALPAK AGP® has extremely broad applicability for the separation of chiral drugs.

  • The chiral selector is alpha1-acid glycoprotein (AGP). This very stable protein is immobilized onto spherical 5 micrometer silica particles. 
    The CHIRALPAK®AGP column separates enantiomers of an extremely broad range of drug compounds.
    • Amine (primary, secondary, and tertiary)
    • Acids (strong and weak)
    • Nonprotolytes (amides, esters, alchohols, sulfoxides, etc.)

CHIRALPAK CBH

  • The chiral selector is Cellobiohydrolase (CBH). This is a stable enzyme, which has been immobilized onto 5 micrometer spherical silica particles.
  • CHIRALPAK®CBH is used for the separation of enantiomers of basic drugs from many compound classes. CHIRALPAK®CBH separates preferentially compounds containing one or more basic nitrogen’s together with one or more hydrogen accepting or hydrogen donating groups (alcohol, phenol, carbonyl, amide, ether, sulphoxide, ester etc.).

CHIRALPAK HSA

  • The chiral selector is human serum albumin (HSA). The protein has been immobilized onto spherical 5 micrometer particles.
  • CHIRALPAK®HSA is especially suited for the separation of weak and strong acids, zwitterionic and nonprotolytic compounds.

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